EFIRM (Electric Field-Induced Release and Measurement) research and related liquid biopsy publications across research groups. Explore studies of epidermal growth factor receptor (EGFR) mutations, circulating tumor DNA (ctDNA) and other biomarkers.
Explore EFIRM studies, reviews and related liquid biopsy research. Filter by topic, year or evidence type.
14 publications · newest first
Reviews saliva-based liquid biopsy approaches for oral and systemic diseases, including EFIRM and other molecular technologies.
Evidence scope: Review of a research field; not a new validation of an EZLife Bio product.
Discusses EFIRM and sequencing approaches in the developing landscape of salivary biomarkers and early lesion detection.
Evidence scope: Special report; does not establish population screening performance or regulatory authorization.
A preanalytical study includes an EFIRM Alu assay alongside other measurements of cfDNA quantity and quality.
Evidence scope: Conference abstract, not a full peer-reviewed research article. Blood-tube and processing conditions matter.
Investigates four separate electrochemical assays for viral RNA, antigen, binding antibody and neutralizing antibody signals in saliva.
Evidence scope: Separate singleplex tests, rather than four targets measured simultaneously in one well. The viral RNA workflow includes RT-LAMP amplification and restriction digestion; antibody assays use distinct preparation and readout conditions. Not a clinical testing authorization.
Investigates library preparation and methylation profiling of ultrashort single-stranded cfDNA.
Evidence scope: Sequencing methodology; not an EFIRM instrument performance study.
Evaluates EFIRM-based anti-SSA/Ro52 and Ro60 assays in saliva and plasma from two Danish cohorts.
Evidence scope: Cohort-specific research. Read the associated corrigendum with the original paper.
Develops a multiplex single-droplet EFIRM approach for detection of selected ultrashort mutation-containing DNA targets.
Evidence scope: Experimental research configuration; not EFIRM96 product specifications. “EFGR” is retained from the published title.
Evaluates EFIRM detection of the GTS-40-3-2 soybean event, including a blinded study of soybean cargo samples.
Evidence scope: Event-specific research and comparison with real-time PCR; not validation of every GMO event or a current commercial kit. Sample preparation remains assay-specific.
Reports longitudinal molecular observations in saliva from two patients with advanced non-small-cell lung cancer.
Evidence scope: Two case reports cannot establish clinical utility or general monitoring performance.
Characterizes EFIRM assays for selected EGFR variants in plasma and saliva, including analytical performance and specimen handling.
Evidence scope: Performance depends on variant, matrix and validated protocol; not a universal platform sensitivity claim.
Investigates PCR-free mitochondrial DNA recognition for meat species identification using an electrochemical assay.
Evidence scope: Food-sample research with assay-specific sample treatment. Not preparation-free, a universal species panel or a current kit specification. Read the associated corrigendum.
A foundational study investigates selected EGFR variants in saliva and plasma from patients with NSCLC.
Evidence scope: Selected variants and study cohorts; does not demonstrate general cancer screening capability.
Introduces a field-induced release and electrochemical measurement method for exosome-associated RNA and protein markers in a research setting.
Evidence scope: Experimental exosome work, including a tumor-cell-derived mouse model; not a patient screening validation or a default step in every EFIRM assay.
Investigates simultaneous electrochemical measurement of salivary IL-8 mRNA and protein, establishing an earlier research foundation for biomarker sensing.
Evidence scope: Research on specific salivary biomarkers and study samples; not current EFIRM96 specifications or a general cancer screening claim.
Two milestones in published electrochemical sensing and liquid biopsy research.
American Journal of Respiratory and Critical Care Medicine
November 15, 2014 · Volume 190, Issue 10
EFIRM research investigated selected EGFR mutations in saliva from patients with lung cancer. The study was featured on the journal’s cover.
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Clinical Cancer Research
July 1, 2009 · Volume 15, Issue 13
Earlier UCLA research measured salivary IL-8 mRNA and protein using an electrochemical sensor. The cover highlights multiplex oral cancer biomarker detection.
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A 96-electrode research plate for parallel electrochemical measurements.
Explore the measurement principleTwo primary studies provide useful starting points. Read the full methods, controls and analysis before planning an evaluation.
This study does not certify current product performance, clinical utility or a universal detection limit.
Read the 2020 studyA research prototype, not a current purchasable kit specification or a validated diagnostic panel.
Read the 2023 studyThe 2025 and 2026 saliva reviews summarize a developing field. They do not add a new product validation or establish a screening indication.
Explore all publicationsBring a non-confidential target, sample matrix, comparator and evaluation objectives.
Research use only. Published target detection without polymerase chain reaction (PCR) uses enzyme-mediated signal generation; it does not copy target DNA. These study results are not specifications for an instrument or assay offered today.
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